The expression level status of a large number of proteins encoded by driver genes was highly predictable, with TFRC, ATM, and PIK3CA in low-grade brain glioma; NRAS, FOXO3, MYC, and TP53 in papillary renal cell carcinoma; CDKN1B in HNSC; and MYC in SARC, exhibiting the top performance with AUCs ranging 0.835-0.974. The gene discussed is PIK3CA; the disease is brain glioma.