One of the downregulated genes in the piperlongumine-based signature, overlapping with the AML-cell line data (Supplementary Table 5), is PTPN6 (also known as SHP-1), a tyrosine phosphatase that has been shown to interfere with cellular senescence via p16 signaling, and was proposed to regulate senescence in nasopharyngeal carcinoma cells78. The gene discussed is CDKN2A; the disease is acute myeloid leukemia.