This compound reduces the number and tumor size by decreasing the cell proliferation and down-regulating the expression of some factors such as the proliferating cell nuclear antigen (PCNA), thymidylate synthase, HGF, and its receptor c-Met; conversely, it up-regulates the expression of the cell cycle inhibitor protein p273,4, suggesting that IFC-305 prevents hepatic tumorigenesis3. Here, PCNA is linked to neoplasm.