In addition, the expression levels of mRNAs that codified the respirosome assembly (Cox7a2l, Uqcc3, and Higd2a) (Fig. 4D) and the structural maintenance of the mitochondrial cristae (Opa1 and indirectly Yme1l and Spg7) were determined (Fig. 4E); the results showed a decrease in the expression levels of Cox7a2l, Uqcc3, and Higd2a in the HCC condition compared to the control group; nevertheless, the expression of these evaluated mRNAs is similar to the control group in the HCC/IFC-305 one. The gene discussed is HIGD2A; the disease is hepatocellular carcinoma.