Concurrently, the participation of structures related to the assembly of supercomplexes, such as COX7A2L, UQCC3, and HIGD2A, whose relevance lies in the correct function of the respirosome formed by complexes I, III2, and IVn, has been reported20; our data supported these conclusions since we found a considerable decrease in expression levels of mRNAs in the HCC condition, which correlates with the structural (formation of supercomplexes) and functional (ATP production) nature. The gene discussed is COX7A2L; the disease is hepatocellular carcinoma.