To identify novel regulators of post-transcriptional and translation control in AML, we surveyed several genome-wide CRISPR screens and observed that several subunits in the RNA deadenylation CCR4-NOT complex i.e. CNOT1, CNOT2, and CNOT3, and CNOT10 were highly ranked among genes essential for survival of human40 and mouse41 leukemia cells (Fig. 1A and Supplementary Fig. 1A). The gene discussed is CNOT1; the disease is acute myeloid leukemia.