To further evaluate the importance of CNOT3 function in human AML, we surveyed CNOT3 expression and found that high CNOT3 expression correlates with poor prognosis of AML patients across three independent AML patient cohorts i.e. German AMLCG 1999 trial42 (Supplementary Fig. 1Y); The Cancer Genome Atlas Program43 (TCGA) (Fig. 1U) and beat AML44 (Fig. 1V). Here, CNOT3 is linked to acute myeloid leukemia.