CNOT3 and leukemia: Given its role in post-transcriptional gene expression control, we performed both transcriptomic and proteomic profiling of control vs. shRNA mediated CNOT3 knockdown leukemia cells at ~2 days post transduction, the earliest time point when we obtained a consistent reduction of CNOT3 expression using the two KD-33 and KD-37 shRNAs (Fig. 4A).