CNOT1 and leukemia: To identify novel regulators of post-transcriptional and translation control in AML, we surveyed several genome-wide CRISPR screens and observed that several subunits in the RNA deadenylation CCR4-NOT complex i.e. CNOT1, CNOT2, and CNOT3, and CNOT10 were highly ranked among genes essential for survival of human40 and mouse41 leukemia cells (Fig. 1A and Supplementary Fig. 1A).