IFNG and neoplasm: Following the adoptive transfer, the intrinsic tumor tropism of eMac contributes to the accumulation in the TME, where the locoregional temperature elevation to ~42 °C by an iWarm direct both self-polarization of transferred eMac and re-polarization of TAMs toward antitumoral phenotype under the locoregional secretion of IFN-γ from eMac.