Additionally, 15a induces a viral mimicry response by inducing the expression of endogenous retroviral elements in breast cancer cells, leading to activation of the RIG-I–MAVS pathway induced by high intracellular levels of dsRNA, which in turn enhances the production of type I/III IFN, the transcription of ISGs and the secretion of chemokines. The gene discussed is RIGI; the disease is breast cancer.