The simultaneous inhibition of HDAC3 and DNMT1 using the BG45 and DNMT1 inhibitors 5-azacytidine (AZA), respectively, has been found to induce synergistic DNMT1 downregulation, growth inhibition and apoptosis in multiple myeloma (MM) cell lines and MM patients [34]. The gene discussed is DNMT1; the disease is AL amyloidosis.