Mice treated with UC1MT exhibit enhanced T-dependent immunity by inhibiting the suppressive effects of both exogenous and/or endogenous MT.12, 16 UC1MT has also proven effective as a therapeutic treatment when administered in murine models of IBD and AILI, where it interferes with leukocyte infiltration and inflammation.20, 24 To determine if UC1MT can block the effects of MT on Th1 and Th2 cell chemotaxis toward their cognate chemokines, Jurkat T cells were exposed to SDF-1α or MT in the presence or absence of UC1MT. This evidence concerns the gene CXCL12 and inflammatory bowel disease.