Additionally, it has been reported that the inflammatory process of CRSwNP is mainly mediated by the Th2 cell immune response, of which IL-33 plays a critical role in the development and regulation.13, 14 However, to our knowledge, there remains a dearth of information regarding the interplay between core genes associated with CRS and the genes involved in the IL-33/ST2 signaling pathway. This evidence concerns the gene IL33 and congenital rubella syndrome.