In this study, we focused on the functional role of PIK3R1-CCDC178 fusion initially identified by genome-wide RNA sequencing in two out of three tumors of an HGSC patient: a lesion in the right ovary and in metastasis of a right para-aortic lymph node but not in another right ovarian tumor lesion [5]. The gene discussed is CCDC178; the disease is ovarian neoplasm.