A recent study on the prognostic and immunomodulatory roles of schizophrenia-associated genes in pan-cancer revealed that PRODH is poorly expressed in lung adenocarcinoma and lung squamous cell cancer, leading to poor prognosis.[53] Additionally, another study identified three independent loci jointly associated with schizophrenia and lung cancer, suggesting a potential downstream polyphenic effect.[54] Our study complements previous research and contributes to a broader understanding of the relationship between schizophrenia and lung cancer. This evidence concerns the gene PRODH and cancer.