CLOCK and cancer: The mechanism by which MLT induces sleep is not through direct hypnotic effects but by resetting the body’s internal clock to match the environmental clock, resulting in normalization of both physiological and behavioral sleep patterns in patients.[14] Circadian rhythm dysregulation is a central mechanism of CRF.[15] Sleep patterns in patients with cancer are often characterized as abnormal and frequently disrupted, potentially resulting in skewed or unsettled circadian rhythms.