GPX4 and cancer: Based on its unique function, GPX4 is considered to be a potent inhibitor of ferroptosis and plays a key role in regulating ferroptosis.[44,45] It has been reported that GPX4 is commonly expressed in cancer cells to manipulate ferroptosis sensitivity, and the compound RSL3, which promotes ferroptosis, directly inactivates GPX4, while another compound, erastin, inactivates GPX4 by inhibiting cytosolic cystine input.[38,46] In addition, Buthionine sulfoximine can induce ferroptosis or enhance cellular sensitivity to ferroptosis induced by other drugs by inhibiting GCL.[47]