CTLA4 and cancer: The status of T cell infiltration and its characteristics are correlated with different prognostic outcomes in cancers.[55] A previous study found that exhaustion markers, such as LAYN, CTLA4, and CXCL13, are associated with T cell exhaustion and prognosis.[56,57] From these results, we hypothesized that the function of CD8Gs in HCC is possibly regulated by activating these subgroups in the HCC microenvironment, which requires further validation.