CD8A and neoplasm: For example, the accumulation of CD8+ T cells at tumor sites was negatively related to tumor stages and positively related to clinical outcomes in breast cancer.[28–30] The presence of highly increased tumor-infiltrating CD8+ T cells had a favorable prognosis in ovarian cancers, pancreatic, oral squamous cell, and colorectal.[31–36] Next, we obtained 416 CD8Gs that were identified and enriched in immune-related signaling pathways, revealing the potential immune regulation of CD8Gs in HCC.