AGT is a major effector of the RAAS system that activates the mitogen-activated protein pathway and may have toxic effects on myocardial cells.[27] In addition, increased plasma renin activity is associated with mortality in CAD patients.[28] AGT polymorphisms are likely to play a role in CAD pathogenesis by increasing plasma angiotensin levels.[29,30] Two SNPs, rs5051 and rs699, are in tight linkage disequilibrium.[30]. Here, REN is linked to coronary artery disorder.