DHODH and cancer: These reactions interfere with cellular metabolism ingeneral but are particularly harmful to cancer cells given their elevatedoxidative stress14 and dependency on glucoseuptake.15In vitro and in vivo studies have analyzed potential effects on proteins,enzymes, and genes involved in redox homeostasis whose functioningbecomes altered by these catalytic processes, such as, glutathioneperoxidase (GPX4),16 dihydroorotate dehydrogenase(DHODH),17 or hypoxia-induced factor (HIF-1)18 among others.