After traveling through the microfluidic device, mitochondrial released endonuclease G into recipient cells (named unsealed mitochondria). Unsealed mitochondria did not induce apoptosis, but the recipient cells were more chemosensitive to doxorubicin and induced apoptosis in response to caspase-3. Doxorubicin experiments were repeated with MDA-MB-231 and MCF7 breast cells with similar results. In vivo, a low dose of doxorubicin with unsealed mitochondria inhibited tumor growth which was not seen in doxorubicin-only control mice. Here, CASP3 is linked to neoplasm.