For example, when HER2−/ER+/PR+ breast cancer cells (MCF7 and T47D) were exposed to hypoxic culturing conditions, these cells released small extracellular vesicles that, upon uptake by MCF10A cells, resulted in altered mitochondrial dynamics, increased migration, and an increased mesenchymal phenotype in these recipient cells. This evidence concerns the gene ERBB2 and breast carcinoma.