MFN1 and breast cancer: Indeed, a similar effect of decreased lamellipodia formation was seen in breast cancer cells (MDA-MB-231, and MDA-MB-436) by altering the expression of fission and fusion molecules, Drp-1 and Mfn1, respectively, wherein “pro-fission” cells (i.e. high Drp-1 and/or decreased Mfn1 expression) with short networks of tubular or spherical mitochondria were more highly migratory [30].