Nevertheless, loss of JMJD6 induced an induction of gene signatures related to axon, neuron projection, and Schwann cell differentiation (Figure 3—figure supplement 2B), which is consistent with the induction of neurite outgrowth observed in BE2C cells after JMJD6 knockdown (Figure 2—figure supplement 2D), indicative of neuroblastoma cell differentiation. The gene discussed is JMJD6; the disease is neuroblastoma.