JMJD6 and cancer: To test this hypothesis, we analyzed the dependency correlation of JMJD6 knockout and other genes (defined as co-dependency genes if they are positively correlated), by using the DepMap data (https://depmap.org) that includes genome-wide knockout in 1027 cell lines of more than 20 cancer types (Figure 3A–D; Figure 3—source data 1), followed by pathway enrichment.