Here, we show a new mechanism by which JMJD6 promotes tumorigenesis mediated by the MYC oncogene in that JMJD6 interacts with a subset of RNA binding proteins including RBM39 in neuroblastoma cells and regulates the alternative splicing of metabolic genes that are involved in mitochondrial metabolism. The gene discussed is JMJD6; the disease is neuroblastoma.