However, BRD4 inhibitors drastically inhibited both MYCN and MYC expression in neuroblastoma cells (Lovén et al., 2013; Chapuy et al., 2013; Puissant et al., 2013), suggesting that JMJD6 inhibition has a distinct effect from the BRD4 inhibition. This evidence concerns the gene BRD4 and neuroblastoma.