We and others have recently reported that indisulam, a ‘molecular glue’ that selectively degrades the splicing factor RBM39, is exceptionally effective at causing tumor regression in multiple high-risk neuroblastoma models without overt toxicity (Singh et al., 2021; Nijhuis et al., 2022), suggesting indisulam has translational potential. Here, RBM39 is linked to neoplasm.