These findings are particularly interesting because BRD4 occupies exceptionally large super-enhancers associated with genes, including MYC and MYCN (Lovén et al., 2013; Chapuy et al., 2013; Puissant et al., 2013), and the expression of those enhancers can be disrupted by BRD4 inhibitors, which have a potent anti-tumor effect (Lovén et al., 2013; Chapuy et al., 2013; Puissant et al., 2013; Wyce et al., 2013). Here, BRD4 is linked to neoplasm.