MYC and cancer: The increase in total RNA and protein synthesis by overactive MYC signaling leads to dysregulation of macromolecular processing machineries including the spliceosome (Hsu et al., 2015), and consequently pre-mRNA splicing (Hirsch et al., 2015; Koh et al., 2015; Phillips et al., 2020), another hallmark of MYC-driven cancers (Hsu et al., 2015; Koh et al., 2015; Phillips et al., 2020; Anczuków and Krainer, 2015; Zhang et al., 2016), for the purpose of cellular stress adaptation.