Children aged ≥18 months with metastatic disease and patients with MYCN amplification tumors are classified as high-risk, which requires a multimodal therapy including induction chemotherapy, surgical resection of primary disease, consolidation with high-dose chemotherapy and stem cell rescue, radiotherapy, and post-consolidation treatment with cis-retinoic acid and immunotherapy (Morgenstern et al., 2019). The gene discussed is MYCN; the disease is metastatic neoplasm.