The data showed that JMJD6 co-dependency genes were significantly and positively correlated with spliceosome/mRNA splicing (i.e. RBM39, SF3B1), ubiquitin-mediated proteolysis and endocytosis and a number of 17q25 genes (Figure 3A and C), which mirrored the pathway network of 17q essential genes in neuroblastoma (Figure 1B). Here, SF3B1 is linked to neuroblastoma.