NPTX2 and early-onset autosomal dominant Alzheimer disease: Several of these 29 genes have been previously reported to be associated with Alzheimer's Disease: overexpression of ANGPT1* has been found to increase amyloid beta secretion (Peng et al., 2020) whilst CLEC4G suppresses amyloid beta (Kizuka et al., 2015), and increased levels of ENC1 (Gns et al., 2022; White et al., 2017) and NPTX2 (Belbin et al., 2020; Libiger et al., 2021; Shao et al., 2020; Xiao et al., 2017) are consistently demonstrated to have protective effects against cognitive decline in Alzheimer's disease.