MAPT and tauopathy: To explore whether blocking NLRP3 acetylation and NLRP3 inflammasome activation induced by Tau can prevent microgliosis in Tauopathies, we designed a peptide TNB (LEDLEDVDLKKFKMHLEDYPP) based on region of NLRP3 binding with Tau to competitively inhibit Tau–NLRP3 interaction.