To clarify whether Tau pathology can drive microglia‐mediated neuroinflammation during prodromal stage of Tauopathy and to uncover the related underlying mechanisms, in the present study, we selected to explore the effects of several ‘early’ pTau proteins on the activation of NLRP3 inflammasome in BV‐2 microglial cells. The gene discussed is MAPT; the disease is tauopathy.