To further confirm the role of Tau‐induced NLRP3 acetylation in the development of neurodegeneration in Tauopathy, we injected AAV carrying Tau441 (AAV‐Tau441), TauS262E (AAV‐TauS262E), TauK18– (AAV‐TauK18–, loss of acetyltransferase activity) or the vector control with 3×Flag‐mCherry into hippocampal CA1 region of 3‐month‐old C57BL/6 mice (Figure 4A). Here, MAPT is linked to tauopathy.