Therefore, these results stand for a hypothesis that NLRP3 inflammasome activation in Tauopathy transgenic mice and AD patients is mediated by NLRP3 acetylation, which is partly illustrated by the high correlation between NLRP3 acetylation level and IL‐1β or cleaved Caspase‐1 level. The gene discussed is NLRP3; the disease is tauopathy.