After Efm pretreatment, there were no significant difference in GSH-Px, GSH, MDA, ET-1, NO, MPO, TNF-α, IL-1β, and IL-10 contents compared with the OME group (P > 0.05); GSH-Px, GSH, MDA, MPO, TNF-α, and IL-1β contents were markedly improved compared with the EtOH group (P < 0.05). Here, IL10 is linked to otitis media with effusion.