This recruitment is mediated through production of proinflammatory chemokines by a newly discovered subtype of LECs expressing pentraxin 3 (Ptx3), termed immune-interacting LECs (iLECs), located at lymphatic capillary terminals, that was found to increase in number in the murine LM lesions (51) (Figure 2). This evidence concerns the gene PTX3 and lymphangioma.