These included AsPC-1 pancreatic cancer orthotopic xenografts and pancreatic cancer patient-derived xenograft (PDX) PAXF1861, both with loss-of-function RNF43 mutations, and a colorectal PDX with an R-spondin translocation (Figure 1, B and C). The gene discussed is RNF43; the disease is familial pancreatic carcinoma.