These data are similar to our findings in Wnt-high pancreatic cancer xenografts and support the model that elevated Wnt/β-catenin signaling represses FAXDC2 expression, decreasing flux through the KR branch of the cholesterol biosynthesis pathway, leading to the accumulation of upstream intermediates, including lophenol and other C4-methyl sterols. Here, FAXDC2 is linked to familial pancreatic carcinoma.