HMGCR and breast carcinoma: However, the LOO analysis suggested that the causal effects between anti-inflammatory and antirheumatic products, nonsteroids, and antihistamines for systemic use and breast cancer, HMG CoA reductase inhibitors, salicylic acid and derivatives, and lung cancer are influenced by individual SNPs, and these MR estimates were not robust (Figure S5 in the Online Supplementary Document).