CRHR1 and Anxiety: Emotionally arousing stimuli promote the release of stress hormones which can enhance later memory consolidation by acting on adrenoreceptors within the BLA.76 Like the DRD, the BLA is an extrahypothalamic source of CRF-containing neurons and many neurons express CRF1 and 2.56 CRF tone rises in the amygdala following exposure to stressors (e.g. acute restraint and ethanol withdrawal) in rats.77 Conversely, rats display anxiety behaviours (spent less time in the open arm of an elevated plus maze) after injections of a CRF1 and 2 agonists (UCN) into the BLA over 5 days.78