Supporting a role for IFIH1 in diabetes-linked B cell activation, a recent study demonstrated enhanced Ifih1 gene expression in B cells from a NOD-Rag1-/- somatic cell nuclear transfer (SCNT) B cell receptor model (B1411), which utilized pancreas-infiltrating B cells as donors for SCNT, allowing endurance of B cells in the absence of T cells (39). The gene discussed is RAG1; the disease is diabetes mellitus.