STIM1 and Hypertension: However, CRAC currents emerge in dedifferentiated fibroproliferative noncontractile arterial myocytes because of increased expression of Stromal Interacting Molecule (STIM1) and Orai1.1,2 Dedifferentiated myocytes (called synthetic) are a hallmark of neointimal hyperplasia in diseases such as hypertension, restenosis, and atherosclerosis.