These alterations impact disease progression and the expression of key genes.246,247 Histone modifications are also involved in RA, with histone H3 in the promoter region of the IL-6 gene being highly acetylated in fibroblast-like synoviocytes (FLS) from RA patients, leading to increased IL-6 expression and disease progression. This evidence concerns the gene IL6 and rheumatoid arthritis.