In one study, miR-22 was shown to reduce the expression of Beclin1, LC-3, MTDH, and ATG5 mRNA by targeting MTDH, thereby inhibiting autophagy and suppressing osteosarcoma cell proliferation.233 Conversely, inhibiting autophagy was found to promote osteosarcoma cell proliferation in another experiment. The gene discussed is MAP1LC3A; the disease is osteosarcoma.