MTDH and osteosarcoma: In one study, miR-22 was shown to reduce the expression of Beclin1, LC-3, MTDH, and ATG5 mRNA by targeting MTDH, thereby inhibiting autophagy and suppressing osteosarcoma cell proliferation.233 Conversely, inhibiting autophagy was found to promote osteosarcoma cell proliferation in another experiment.