AKT1 and rheumatoid arthritis: By inhibiting the AKT/mTOR pathway and activating autophagy, MEG3 suppresses inflammation, promotes chondrocyte proliferation, and inhibits RA progression.253 In experiments by Zhou et al. using a CIA rat model, it was confirmed that treatment with WJR (Wenhua Juanbi Recipe) may inhibit autophagy by affecting the PI3K/AKT/mTOR pathway mediated by miRNA-146a.