FEN1 and osteosarcoma: MiR-129-5p directly targeted LHX2 3′-UTR to downregulate LHX2, making the miR-129-5p/LHX2/mTOR axis a potential target for osteosarcoma treatment.237 Additionally, DANCR is a lncRNA that acts as a ceRNA by sequestering miR-335-5p and miR-1927 in osteosarcoma, promoting ROCK1-mediated proliferation and metastasis.238 Another study on osteosarcoma reveals that miR-193b directly targets the 3′-UTR of FEN1, negatively regulating the expression of FEN1, increasing the expression of Beclin 1 and the LC3-II/I ratio, activating autophagy, and inducing cell apoptosis.239