ERBB2 and central nervous system cancer: Human Epithelial Receptor Type 2 (HER2) is another tyrosine kinase receptor implicated in gliomas, as HER2 expression is associated with de novo GBM and decreased survival.33 In 2010, Ahmed et al. aimed to evaluate the effectiveness of HER2-specific CAR-T cells created from patients with GBM.34 These CAR-T cells exhibited significant T cell proliferation and cytokine secretion, selectively killing HER2-positive GBM cells in vitro.