One of the clones was discovered to bind to B7-H3, a molecule implicated in immunosuppression.62,63 Promisingly, a B7-H3 targeting CAR was able to lyse GBM cells.62 This has culminated in several ongoing studies involving B7-H3-CAR-T cells in GBM (Table 3).64 The gene discussed is CD276; the disease is glioblastoma.