For example, exploiting gliomas’ affinity for chlorotoxin (CLTX) led to the development of a chlorotoxin-targeting CAR-T cell (CLTX-CAR-T).61 Chlorotoxin binding was observed in almost all 23 patient samples and was independent of IL-13Rα2, HER2, and EGFR expression. Here, IL13RA2 is linked to central nervous system cancer.