SPP1 and neoplasm: The ROC analysis revealed that both MEOX1 (AUC = 0.887, Confidence interval (CI) = 0.849 - 0.926) and SPP1 (AUC = 0.988, CI = 0.979 - 0.997) expression could serve as single significant parameters for discriminating between normal and tumor tissues of ovarian cancer (Figure.