CDK4 and acute myeloid leukemia: Western blot analysis of xenograft tumor issues showed that cycle-related proteins CDK4 and cyclinD1, and apoptotic-related protein Bcl2 expression decreased while that of p21, p53, Bax, and cleaved caspase3 protein increased, suggesting miR-103a-2-5p could affect the cell cycle and apoptosis of AML (Fig. 8E, F).