For instance, Staphylococcus aureus infection (bta05150) pathway was significantly enriched by genes (e.g., CATHL2, CATHL3, KRT18, FGG) harboring DMCs at their first exons as well as differential genes (identified by MethGET) having significant DNA methylation changes in their regulatory regions. The gene discussed is FGG; the disease is staphylococcus aureus infection.