In addition, we detected increased expression of PD-L1 on the NFKBIE-ko leukemia cells as well as increased expression of PD-1, TIGIT and LAG3 on CD4+ and CD8+ T-cells from the spleens of mice with NFKBIE-ko tumors, consistent with the exhausted phenotype predicted by the RNAseq analysis. Here, CD4 is linked to leukemia.