To investigate whether similar changes occur in the human setting, we analyzed the expression of PD-1 and TIGIT on CD4+ and CD8+ T-cells in peripheral blood samples from 11 NFKBIE-mutated (MAF > 0.2) and 11 NFKBIE-wt CLL patients. The gene discussed is NFKBIE; the disease is B-cell chronic lymphocytic leukemia.