IL-1β has been shown to be secreted upon cell death due to plasma membrane rupture24 or pyroptosis, which is a lytic form of cell death that is triggered by Caspase-1 activation25; however, a recent study demonstrated that cell death is not essential for Caspase-1-mediated IL-1β activation and secretion26, and this cell death-independent mechanism likely occurs in CRC cells. Here, IL1B is linked to colorectal carcinoma.