Deletion of synuclein is associated with the development of progressive neurological impairments, while its loss of function/gain of toxicity due to e.g. aggregation is implicated in the pathogenesis of synucleinopathies, neurodegenerative disorders that include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)7,8. Here, SNCA is linked to Lewy body dementia.