The link between α-Syn mutations and deposition of α-Syn in PD brains has encouraged the generation of several lines of α-Syn transgenic mice over the last couple of decades11,20,21, with several models expressing α-Syn with and without pathogenic mutations under the control of different promotor systems, e.g. the prion protein or the neuron-specific Thy-1 promoter. The gene discussed is THY1; the disease is Parkinson disease.