The presence of ETS2 binding sites on the PLAU promoter37suggestes that this transcription factor might be partially involved in the PCOS pathogenesis via XIST- hsa-miR-144-3p, hsa-miR-1271-5p and hsa-miR-146a-5p- ETS2- PLAU axis . This evidence concerns the gene XIST and polycystic ovary syndrome.