In the present study, it was revealed that TNFR1B was significantly upregulated in GCs of PCOS individuals through the suppression of its regulatory miRNA, hsa-miR-193a-3p by XIST. In accordance with our results, studies have reported up-regulation of both TNF receptors in the adipose tissue of obese women. Here, XIST is linked to polycystic ovary syndrome.