Similarly, when predicting annual MMSE change in all-cause dementia patients (Fig. 4B) above the pTau217 cutoff, the model containing tau-PET SUVr and demographics showed the highest added prognostic value and performed significantly better (R2 = 25.6%; wAIC = 0.75), when compared to the demographics-only (R2 = 0.2%; wAIC = 0) and plasma pTau217 plus demographics (R2 = 7.7%; wAIC = 0) models. The gene discussed is MAPT; the disease is dementia.