KRAS and cancer: Cancer-relevant KRAS mutations are classified into three categories73 based on their impact on KRAS protein functions: Class I (Hydrolysis) includes mutations leading to the loss-of the GTP-hydrolyzing feature of KRAS, Class II (Exchange) involves mutations causing a gain in KRAS Exchange function facilitated by Guanine Nucleotide Exchange Factors, and Class III (Hybrid) encompasses mutations affecting both functions.