Furthermore, IHC staining showed that shmiR-5100 reversed HIF1α-induced regulation of the expression of QKI, E-cadherin, and N-cadherin in HNSCC xenografts (Fig. 2H), confirming the effect of HIF1α/miR-5100 axis on QKI and EMT process. The gene discussed is CDH2; the disease is head and neck squamous cell carcinoma.