Among these candidates, miR-5100 was increased when HNSCC cells were exposed to hypoxia, while HIF1α knockdown reduced the level of miR-5100 in hypoxic SCC15 and HN4 cells (Fig. 1E), revealing a positive correlation between hypoxia/HIF1α and miR-5100. The gene discussed is HIF1A; the disease is head and neck squamous cell carcinoma.