UBE2V1 enhances the metastasis of CRC by facilitating the ubiquitination and degradation of Sirt1 with the assistance of UBC13 (a significant cofactor of UBE2V1), leading to the inhibition of histone H4 lysine 16 acetylation and ultimately suppressing the expression of autophagy genes in CRC [22]. The gene discussed is UBE2N; the disease is colorectal carcinoma.