Specifically, SIRT5 overexpression reduced the IC50 of 6-MP in 6-MPR B-ALL cells (Fig. 4K and S4L), suppressed cell proliferation (Fig. 4L and S4M), and promoted 6-MP-induced apoptosis (Fig. 4M and S4N). The gene discussed is SIRT5; the disease is acute lymphoblastic leukemia.