SIRT5 and leukemia: To test whether the effects on leukemia cells induced by SIRT5 were mediated by its enzymatic activity, cell lines overexpressing wild-type SIRT5 (SIRT5-WT) and SIRT5-H158Y, a catalytically inactive mutant of SIRT5 [28, 29, 35], were established using specific plasmids (Fig. S4K).