GPI for GPI-APs, such as PrPC, plays a crucial role in protecting neurons, which is reflected in the fact that GPI is indispensable for PrPC to protect and repair the neuronal cytoskeleton and neuronal communication.409 Many neurological disorders exhibit pathological shifts stemming from downregulated cell surface GPI-AP expression, often linked to mutations in genes responsible for GPI-AP biosynthesis and remodelling. Here, PRNP is linked to nervous system disorder.