FLT3 and acute myeloid leukemia: FLT3 is a receptor tyrosine kinase that is mainly involved in haematopoietic development, and FLT3 internal tandem repeat (FLT3-ITD) is a common mutation in acute myeloid leukaemia (AML).93 FLT3-ITD is mainly localised to the ER rather than the PM, but increased PM localisation of FLT3-ITD was found after mutation of the palmitoylation site Cys563 and disruption of its S-palmitoylation, which was subsequently followed by the activation of Akt and ERK as well as sustained STAT5 activation, finally promoting the development of AML.93