The overactivation of the PI3K/Akt signalling pathway abnormally regulates cell-cycle progression, cell proliferation and metabolism, which is an important factor in the progression of a variety of tumours and other diseases.118 Recently, accumulating evidence demonstrated the role of S-palmitoylation in regulating the PI3K/Akt signalling pathway. The gene discussed is AKT1; the disease is neoplasm.