PRKAB1 and rheumatoid arthritis: Specifically, low expression of NMT1 inhibited myristoylation-dependent AMPK lysosomal trafficking and activation, which resulted in the overactivation of mTORC1 signalling in CD4 T cells and contributed to the differentiation of CD4 T cells into pro-inflammatory Th1 and Th17 cells209,218 Moreover, a strong anti-inflammatory effect could be achieved by overexpressing NMT1 in RA T cells with low NMT1 expression.