FLT3 is a receptor tyrosine kinase that is mainly involved in haematopoietic development, and FLT3 internal tandem repeat (FLT3-ITD) is a common mutation in acute myeloid leukaemia (AML).93 FLT3-ITD is mainly localised to the ER rather than the PM, but increased PM localisation of FLT3-ITD was found after mutation of the palmitoylation site Cys563 and disruption of its S-palmitoylation, which was subsequently followed by the activation of Akt and ERK as well as sustained STAT5 activation, finally promoting the development of AML.93 Here, AKT1 is linked to acute myeloid leukemia.