SMO and medulloblastoma: Inhibition of HMG-CoA reductase by statins reduces cholesterol biosynthesis, markedly decreases Hh pathway activity and represses the proliferation of medulloblastoma cells.314 In addition, it is speculated that inhibition of sterol biosynthetic enzymes to divert sterol flux away from cholesterol into a “shunt” pathway may impair SMO activation by depleting cellular cholesterol, while more preclinical and clinical data are needed to support its application for SMO inhibition.