When RCE1 is conditionally deleted, Ras loses its capability to participate in endoproteolysis and methylation, leading to the partial mislocalization of K-Ras and H-Ras, which retards cell growth, reduces Ras-induced transformation, and sensitises tumour cells to farnesyltransferase inhibitors.352 Inactivating ICMT activity has stronger implications in disrupting oncogenesis than activating RCE1. The gene discussed is HRAS; the disease is neoplasm.