AKT1 and cancer: Accumulating evidence suggests that myristoylation has a substantial impact on various signalling pathways that directly or indirectly regulate cancer, metabolism, immunity and others, such as the Src signalling pathway,199 AMPK signalling pathway,200 Wnt signalling pathway,201 PI3K/Akt signalling pathway,202 Notch signalling pathway,203 the LPS-induced TLR4 inflammatory response,204 the cGAS-STING signalling pathway,205 the B-cell receptor pathway206 and pathways involved in T-cell development207 (Fig. 6).