LEP and obesity due to melanocortin 4 receptor deficiency: Similar to type 2 diabetes, obesity is affected by saturated FA-mediated activation of the JNK pathway.216 In addition, abnormal regulation of leptin signalling is quite common in the development of obesity, and studies have shown that it is myristoylated Akt but not nonmyristoylated Akt that induces increased leptin levels in 3T3-L1 adipocytes,217 which indicates that targeting Akt myristoylation may present a promising way to improve obesity.