Epithelial ovarian cancer relies on the tricarboxylic acid cycle and oxidative phosphorylation to meet its anabolic growth requirements.125 S-palmitoylation increases the activity of the key tricarboxylic acid cycle enzyme MDH2 to support mitochondrial respiration and tumour cell proliferation, and the increased S-palmitoylation was attributed to the enhanced binding of DHHC18 to MDH2.125. Here, MDH2 is linked to ovarian carcinoma.