Protein S-palmitoylation plays a regulatory role in the brain, and dysregulation of protein S-palmitoylation has been found to be closely related to a variety of neurodegenerative diseases.132 Using Parkinson’s disease (PD) as an example, we will briefly discuss how aberrant S-palmitoylation regulation contributes to the aggregation of nonfunctional proteins, affecting the pathogenesis and progression of PD. Here, PROS1 is linked to Parkinson disease.