Studies initially found that NIP71 was negatively correlated with the expression of the NMT substrate pp60Src, and subsequently revealed that purified NIP71 and HSC70 could inhibit human NMT in a dose-dependent manner.226,227 Similarly, enolase was found to inhibit human NMT activity in a dose-dependent manner.228 The discovery of these biological NMT inhibitors has broadened the strategy of targeting NMT for the treatment of tumours, but more studies are needed to confirm the effectiveness of their application. The gene discussed is NMT1; the disease is neoplasm.