uPAR–α5β1 integrin interaction signals to FAK and then activates EGFR, and uPAR–β1 integrin–EGFR signalling enhances ERK activation to promote cancer cell proliferation.405 The importance of these GPI-APs in cancer also implies that GPI-T may act as an oncogene in tumour development. The gene discussed is EGFR; the disease is neoplasm.