BARD1 and neoplasm: Because somatic pathogenic variants occurring as a second hit in the intact BARD1 allele, homologous recombination deficiency status, and the mRNA-level expression status of each isoform from each BARD1 allele were not analyzed in the tumor tissues from this patient, it is unclear whether the detected germline BARD1 variant contributed to the pathogenesis of CRC or was just an incidental alteration; if the former is true, how this variant may cause CRC is also unknown.