WHO2022 defines this category as “AML myelodysplasia-related (MR)” and includes a set of eight genes (ASXL1, BCOR, EZH2, SF3B1, SRSF2, STAG2, U2AF1, and ZRSR2) for AML-MR diagnosis [1]. The gene discussed is EZH2; the disease is acute myeloid leukemia.