This guideline also provides a basic set of genes that covers a large proportion of patients with AML: CALR, CEBPA, DDX41, ETV6, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NPM1, NRAS, PTPN11, RAD21, RUNX1, SF3B1, SRSF2, STAG2, TP53, U2AF1, and WT1 (Table 1). The gene discussed is SF3B1; the disease is acute myeloid leukemia.