In heart failure, lncRNA NEAT1 was found to provide scaffolding between the enhancer of zeste homolog 2 (EZH2) and the Smad7 promotor region similar to lncRNA MALAT1, thereby decreasing the expression of Smad7 and leading to unbalanced TGFβ–driven fibrosis [92]. The gene discussed is NEAT1; the disease is heart failure.