MALAT1 and diabetic cardiomyopathy: Known biomolecules have been hypothesized to affect lncRNA MALAT1; for example, the pineal gland hormone and common sleep aid melatonin were shown to have an antifibrotic effect in a model of diabetic cardiomyopathy by inhibiting lncRNA MALAT1 and miR-141-dependent NLRP3 inflammasome activation [78].