HAVCR2 and T-cell non-Hodgkin lymphoma: In humans, germline autosomal recessive TIM-3 deficiency (p.Tyr82Cys, p.Ile97Met) predisposes to rare subcutaneous panniculitis-like T cell lymphoma (SPTCL) complicated by hemophagocytic lymphohistiocytosis (HLH) [5].