TXNIP and cancer: Similarly, Txnip KO EBs showed highly delayed or reduced gene expressions than WT EBs in cluster 7 and 8 (Fig. 3C), including gene ontologies of “angiogenesis”, “cell migration”, and “multicellular organism development” (Fig. 3D) and pathways of “FoxO signaling”, “MAPK signaling”, and “cancer” (Fig. 3E).