To further explore the role of TWIST1 in MET driven NSCLC in vivo, we silenced TWIST1 in the MET exon 14 skipping mutant NSCLC cell line H596 and found that genetic inhibition of TWIST1 led to a significant decrease in tumor growth (68% reduction in mean tumor size) (Fig. 2G). This evidence concerns the gene TWIST1 and neoplasm.