We next overexpressed FBW7β in the human B-cell lymphoma cell lines SU-DHL-4 and FARAGE, and found that BCL6 expression dramatically decreased following overexpression of FBW7β in both cell lines; levels of c-MYC and c-JUN, two well-characterized canonical FBW7 substrates, were used as positive controls (Fig. 6B). The gene discussed is JUN; the disease is B-cell non-Hodgkin lymphoma.