Moreover, stress oncoproteins have been reported to be important in sensitizing chemoresistant mCRPC cells to taxanes.25 Thus, we suggest synergistically disrupting redox adaptation with the agents targeting p-NF-κB is most likely to improve the apoptotic effect of Cab in aggressive PC cells via selective inhibitors of the indicated pathway. The gene discussed is NFKB1; the disease is pachyonychia congenita.