SYK and neoplasm: Dectin-1 is not normally expressed in human pancreatic cells.149 However, it has been identified in association with inflammation caused by Malassezia folliculitis .14 Dectin-1 functions, particularly in fungal infections, by initiating the Syk-CARD9-NFκB pathway and activating the downstream caspase-8-ASC complex, ultimately leading to the production of IL-1β.12,150,151 Alam et al. discovered that this Dectin-1 pathway contributes to the pathogenic pathway of Malassezia through activation of cytokines IL-33 from PDA cells, a downstream target of KrasG12D in tumor-bearing mice.